Evan Seitz
Evan Seitz
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Analysis of Conformational Continuum and Free-energy Landscapes from Manifold Embedding of Single-particle Cryo-EM Ensembles of Biomolecules
Evan Seitz
February 2022
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Abstract
Columbia Libraries: Doctoral Thesis, 2022
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Thesis
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Columbia University Libraries
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Recovery of conformational continuum from single-particle cryo-EM images: Optimization of ManifoldEM informed by ground truth
Geometric machine learning informed by ground truth: Recovery of conformational continuum from single-particle cryo-EM data of biomolecules
POLARIS: Path of least action analysis on energy landscapes
Simulation of cryo-EM ensembles from atomic models of molecules exhibiting continuous conformations
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